UPDATE: Not CGI.
In the most recent episode of It's Always Sunny in Philadelphia — "The Gang Wrestles for the Troops," which aired on Thursday — Pub & Kitchen makes a cameo.
They show an exterior shot of the bar/restaurant on the corner of 20th and Lombard (still, above) and then do a scene where Artemis meets Sweet Dee inside. However, the interior scenes were not actually shot at Pub & Kitchen.
So it's actually a very short cameo.
But regardless, good location choice by production team.
It's Always Sunny In Philadelphia [ Official Site ]